[00051 It is estimated that ADHD affects about 4% to 6% of the U. Approximately one-half to two-thirds of children with ADHD will continue to have significant problems in adulthood and experience difficulties which impact employment, familial, and social relationships.  Figures 1 1 A-B: Photographs of improvement in wound healing for Ms. Mammalian species which benefit from the disclosed methods include, and are not limited to, apes, chimpanzees, orangutans, humans, monkeys; domesticated animals (pets) such as dogs, cats, guinea pigs, hamsters, Vietnamese pot-bellied pigs, rabbits, and ferrets; domesticated farm animals such as cows, buffalo, bison, horses, donkey, swine, sheep, and goats; exotic animals typically found in zoos, such as bear, lions, tigers, panthers, elephants, hippopotamus, rhinoceros, giraffes, antelopes, sloth, gazelles, zebras, wildebeests, prairie dogs, koala bears, kangaroo, opossums, raccoons, pandas, giant pandas, hyena, seals, sea lions, and elephant seals.
A crucial element requires that the behaviors must create a real handicap in at least two areas of a person's life, such as school, home, work, or social settings. The th,ee pa«er»s wi* / T ""P'oved,' .„ 'markedly i-p— wb«, ont^t ■» ■ or »Pi--n,aybav.s™„L^jr ^ "^'^ ^ ~TU:^teter "".'^ for «e Guzman, B. G.; Zhou, Y.; Chavez, JM.; ■-*=..io„ » d^Mreo ""^ '""^ «i.o™.« WOO'2/43731 PCT/USOl/44923 4 D. I., "Carbamazepine for intermittent explosive disorder in a Prader-Willi syndrome patient", J Clin Psychiatry 3 (1987)). Also very conunon in PWS are behavioral and psychiatric manifestations. gougmg, nail biting, and skin picking), explosive outbursts, oppositional behavior, obsessive ruminations, and compulsive behaviors including hoarding, counting, and arranging.  For compounds of formula I, Ri may be hydrogen or an alkyl of about 1 to 4 ca Aons, such as methyl, etiiyl, and isopropyl. For compounds of formula I, Alkyl groups for R2, R3, R4, Rs, Rd, and R? 7'""'' the terms alkyl and alkoxy include straight (il) are those wherein the pyran rine is in the T =«,t, Hyf«»n rmg IS m the L-sorbopyranose absolute confimiratiftn P Particularly prefix M„ge, Ki„„j^^b,^,,y^^^.^ * hydroge,.
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The invention also provides therapeuucally ^ effective compositions comprising one or more of the compounds of formulas l-V.  Figure 16 illustrates the reported reduction in the urge of Ms.  Figure 17 represents the improvement in impulse control for Ms.
BNSDCXID: wo 02/43731 PCT/USOI/44923 DESCRJPTTn M HEALING Crogs^Reference to Relat P^ Appi.y,^-^^ The present claims the benefit nf tt q p™ • • November 30 .000 which TT""-''^'''''''^ ^^^^^^ i O, .000. Brief Summa Tv of the Invmrir.^ explosive dis»*r " « i*"™**™ P c^^d^rde. c wo 02/43731 o PCT/USOl/44923 8 Brief Description of the Drawings 100181 The patent or application file contains at least one drawing executed in color. A during treatment using the Gordon Diagnostic System.